IntroductionThe assessments of the motor symptoms in Parkinson’s disease are usually limited to clinical rating scales, and it depends on the clinician’s experience. This study aims to propose a machine learning technique algorithm using the variables from upper and lower limbs, to classify people with PD from healthy people, using data from a portable low-cost device. And can be used to support the diagnosis and follow-up of patients in developing countries and remote areas.MethodsWe used Kinect®eMotion system to capture the spatiotemporal (...) gait data from 30 patients with PD and 30 healthy age-matched controls in three walking trials. First, a correlation matrix was made using the variables of upper and lower limbs. After this, we applied a backward feature selection model using R and Python to determine the most relevant variables. Three further analyses were done using variables selected from backward feature selection model, movement disorders specialist, and all the variables from the dataset. We ran seven machine learning models for each model. Dataset was divided 80% for algorithm training and 20% for evaluation. Finally, a causal inference model using the DoWhy library was performed on Dataset B due to its accuracy and simplicity.ResultsThe Random Forest model is the most accurate for all three variable Datasets followed by the support vector machine. The CIM shows a relation between leg variables and the arms swing asymmetry and a proportional relationship between ASA and the diagnosis of PD with a robust estimator.ConclusionsMachine learning techniques based on objective measures using portable low-cost devices are useful and accurate to classify patients with Parkinson’s disease. This method can be used to evaluate patients remotely and help clinicians make decisions regarding follow-up and treatment. (shrink)

En este texto se desarrolla un acercamiento al problema de las formas de acción colectiva y de representación que se pueden presentar como alternativas con potencial de transformación de las condiciones sociales más allá de la estructura ideológica del sistema capitalista. A partir de una confrontación entre Cornelius Castoriadis y Slavoj Žižek con respecto a la posibilidad de autoinstitución de la sociedad y la necesidad de vincular la multitud a una representación unitaria, se analizan los dilemas concretos de lalucha revolucionaria (...) a través de las figuras de Lenin y Robespierre. Este análisis permite concluir que la irrupción de la libertad de los colectivos en los eventos revolucionarios implica un tipo de violencia que impide determinar con certeza su dirección. Sin embargo, tal violencia también es la condición que enmarca el acto revolucionario en una dimensión ética, como una decisión que posibilita la transformación del imaginario. (shrink)

The aim of this review is to identify and provide a structured overview of quantitative models in the pharmaceutical supply chain, a subject not exhaustively studied in the previous reviews on healthcare logistics related mostly to quantitative models in healthcare or logistics studies in hospitals. The models are classified into three categories of classification: network design, inventory models, and optimization of a pharmaceutical supply chain. A taxonomy for each category is shown describing the principal features of each echelon included in (...) the review; this taxonomy allows the readers to identify easily a paper based on the actors of the pharmaceutical supply chain. The search process included research articles published in the databases between 1984 and November 2016. In total 46 studies were included. In the review process we found that in the three fields the most common source of uncertainty used is the demand in the 56% of the cases. Within the review process we can conclude that most of the articles in the literature are focused on the optimization of the pharmaceutical supply chain and inventory models but the field on supply chain network design is not deeply studied. (shrink)

Hannah Arendt’s work is an important reference for Paul Ricœur. Her definition of power as the free action in concert of individuals within a community of equals, guaranteed by institutions, allows Ricœur to ground his reflection on the political dimension of recognition and justice. However, as I will show in this paper, such a definition is problematic, particularly because of the relation that Arendt establishes between power and authority, her decision to separate the social and the political, and her understanding (...) of ideology, philosophy, and common sense in politics. After describing Arendt’s account of the relation between power and authority, I argue that, without rejecting the spirit of her political thought or her basic concepts, Ricœur’s reflections on the functions of ideology in his Lectures on Ideology and Utopia offer a broader but complementary vision that allows us to understand the issues that remain obscure in Arendt’s approach. -/- Résumé: L’œuvre de Hannah Arendt constitue une référence importante pour Paul Ricœur. La définition arendtienne du pouvoir comme agir ensemble des individus au sein d’une communauté d’égaux garantie par des institutions, fournit en effet à Ricœur les bases de sa réflexion sur la dimension politique de la reconnaissance et de la justice. Cependant, cet article s’efforce de montrer qu’une telle définition est problématique, non seulement en raison de la relation qu’Arendt établit entre le pouvoir et l’autorité, mais aussi en ce qui concerne sa distinction du social et du politique, sa compréhension de l’idéologie, ainsi que sa conception de la philosophie et du sens commun dans le domaine politique. Après une analyse des thèses d’Arendt sur la relation entre le pouvoir et l’autorité, cet article soutient que, sans rejeter l’esprit de la pensée politique arendtienne et ses concepts de base, la conception ricœurienne des fonctions de l’idéologie développée dans L’idéologie et l’utopie offre une vision plus ample et plus complète qui permet d’éclairer les questions qui demeurent obscures dans l’approche de Hannah Arendt. (shrink)

Por años, se consideró a las Fuerzas Armadas Revolucionarias de Colombia-Ejército del Pueblo como la principal y más grande insurgencia armada, enemigo número uno del Estado. Así mismo, desde 2012 se adelantó un proceso de diálogo y negociación política entre el gobierno colombiano y dichas fuerzas, que tuvo como resultado poner fin a la confrontación militar de más de seis décadas y habilitar un camino de reformas y apertura democrática para esta organización. Son muchos los factores que explican que la (...) posibilidad real del cese definitivo al fuego entre el establecimiento y las farc-ep haya sido exitosa. Sin embargo, la derrota estratégica de la primera guerrilla colombiana es la menos explorada y de escasos resultados en el subcampo del análisis político. Que la guerrilla de las farc-ep haya ingresado a un proceso de reincorporación no solo se explica por un desgaste obvio de la guerra, o una ventana de oportunidad a la salida política negociada, sino también porque en el plano político-militar hubo un escenario desfavorable que no se logró superar. El presente artículo es el resultado de un estudio con base en el enfoque de análisis de coyuntura, que reconoce un horizonte relacional y estratégico de la acción político-militar que comprende la identificación de actores, acontecimientos, escenarios, correlación de fuerzas y relación estructura-coyuntura a partir de la revisión bibliográfica de expertos y el Centro de Investigación en Memoria Histórica Militar, adscrito al Ministerio de Defensa. (shrink)

El presente artículo recapacita sobre las reformas normativas acontecidas en las últimas décadas respecto al uso racional de los medicamentos, y las medidas operadas en torno a la disminución del gasto farmacéutico. En este contexto, debe destacarse el elevado coste de las terapias biológicas y las dificultades de acceso a las mismas —especialmente en los países en vías de desarrollo—. Los medicamentos biosimilares son poseedores de garantías sanitarias análogas —semejantes o equivalentes— a los medicamentos de referencia, pero no están sometidos (...) a una protección por una patente y facilitan la accesibilidad a los pacientes, así como al reparto equitativo de los recursos terapéuticos. Además, algunos de ellos están incluido en la lista de medicamentos esenciales de la Organización Mundial de la Salud (OMS).Asimismo, se examina el papel de los medicamentos biosimilares como esenciales y la posibilidad de mejorar el acceso equitativo a estos recursos sanitarios a través de la prestación farmacéutica. (shrink)

Jose Marti contributed greatly to Cuba's struggle for independence from Spain with words as well as revolutionary action. Although he died before the formation of an independent republic, he has since been hailed as a heroic martyr inspiring Cuban republican traditions.

Background: Waiving parent permission can be an option in some epidemiological and social research with adolescents. However, exemptions have not been uniformly considered or applied. Our aim is to critically assess the different factors that could be taken into account when making decisions about waiving active parental permission in observational research with adolescents.DiscussionIn some cases alternatives to parental permission could be applied to protect the rights of both adolescents and parents and also to assure the benefits to adolescents as a (...) group that can come from appropriately conducted studies. However, the criteria of ensuring minimal risk can be difficult to define and apply and a distinction between harm and discomfort is reviewed. Waiving active parental permission could be acceptable when the risk of harm is minimal; when the research questions are related to an activity for which adolescents are not legally considered to be children; when the risk of harm or discomfort may increase if parental permission is required; and when risk of discomfort is low because the questionnaire is not potentially offensive for some adolescents and/or for some parents.SummaryStringent rules concerning parental permission in some studies could be detrimental to adolescents. A framework and a decision tree guide are proposed to help researchers and Research Ethics Committees in their decisions on whether active parental permission must be obtained. (shrink)

This book introduces readers to central concepts and ideas in Mexican philosophy. Couched in stories and anecdotes from the author's life, the book offers these concepts and ideas as orientations, recommendations, or exhortation for navigating today's world. The structure and the style of the book aims at making these accessible to both specialists and non-specialist or anyone who may have had some experience with contemporary forms of marginalization, alienation, objectification, or any of the various forms of dread and accidentality familiar (...) to modern life. This, the author thinks, is most of us. Narrowing down the scope of the tradition, the author draws from the history of Mexican philosophy in the 20th century, as it is at this time that Mexican philosophy comes into its own. The book begins with two short introductions, one is an introduction philosophy in Mexico, the other to Mexican philosophy. Here, readers are introduced to Alfonso de la Veracruz, who offered the first philosophy course in the Americas in 1540 in the monastery of a small town in Michoacán, Mexico. From there, it presents four main themes from Mexican philosophy that recur in the philosophical literature. The remainder of the book serves as a "guide" for living a better, more fulfilling life. The main characters in what the author considers an uncontroversial retelling of Mexican philosophy are Antonio Caso, Samuel Ramos, Emilio Uranga, Leopoldo Zea, Jorge Portilla, Rosario Castellanos, Elsa Cecilia Frost, and, of course, persons in the author's own life. (shrink)

La presente propuesta de investigación se promueve desde las áreas de formación ética, filosófica y las ciencias sociales escolares. El objetivo principal es describir los niveles de desarrollo de pensamiento crítico a partir de los ejercicios de lectura compartida y práctica pedagógica elaborados por los estudiantes de la educación media de la jornada tarde del colegio Carlos Albán Holguín. El proceso investigativo se organizó desde los métodos mixtos, a partir del paradigma pragmático y un diseño concurrente. Se tuvo en (...) cuenta desde el enfoque cuantitativo, cuestionarios como instrumentos de recolección de datos, y, del enfoque cualitativo, las técnicas de la observación participante, grupo focal y entrevista semiestructurada. La muestra con la que se implementa la investigación es de 97 estudiantes en edades comprendidas entre los 14 y 19 años. La experiencia ha permitido evidenciar como las prácticas lúdicas de lectura y reflexión ética, filosófica y social permiten generar otros ambientes de aprendizaje de los estudiantes de la educación media y de la básica primaria; asimismo, ha posibilitado fortalecer habilidades socioemocionales y ciudadanas que ayudan a incidir positivamente en la toma de decisiones en temas pertinentes para los jóvenes y niños del contexto donde desarrollan sus quehaceres diarios escolares. (shrink)

Neste artigo, realiza-se uma discussão sobre as atividades políticas de María de Molina, regente do trono castelhano após a morte do esposo e rei Sancho IV, em 1295, durante a minoridade do filho Fernando IV, de 1295 a 1301, assim como no decurso da minoridade do neto Alfonso XI, de 1212 a 1325. Nesses quase vinte e seis anos na condução política do reino, María de Molina constitui-se o principal baluarte da resistência e das negociações dos assuntos do reino (...) diante dos interesses das principiais facções nobiliárias, que aproveitavam períodos de debilidade do poder régio para obter relevância política e dividendos. Não menos importante foi seu desempenho em relação à política externa ao celebrar diversos acordos com outros reinos e com o papado no desígnio de alcançar apoio para sequência da sua linhagem ao comando da coroa castelhana. (shrink)

Antônio de Castro Alves was born on 1 March 1847 on the Fazenda das Cabaceiras (Cabaceiras Farm) in the state of Bahia, and died in July 1871 in Salvador, the state capital. For this short twenty-four year span of his life he represented, as no one else in Brazil did, the myth of the Romantic poet and hero.His literary vocation became clear very early on. Coming from a well-to-do family, he studied law in Recife (the capital of Pernambuco), Salvador and (...) São Paulo. He fell in love with a Portuguese actress, Eugênia Câmara, ten years older than himself, and had the deep experience of a love affair with her that shocked the moral provincialism of contemporary Catholic monarchist Brazil. Like many writers of the period he wrote plays, and had great success with the drama Gonzaga, or the Minas Revolution, about the (abortive) attempt to free Brazil from the Portuguese yoke, which had been made in Minas Gerais in the eighteenth century. But it was in poetry – Espumas flutuantes (‘Floating Foam’, 1870) as well as the posthumous A cachoeira de Paulo Alfonso (‘Paulo Alfonso's Waterfall’, 1876) and Os escravos (‘The Slaves’, 1883) – that Castro Alves stood out on the country's literary scene. (shrink)

Antônio de Castro Alves was born on 1 March 1847 on the Fazenda das Cabaceiras (Cabaceiras Farm) in the state of Bahia, and died in July 1871 in Salvador, the state capital. For this short twenty-four year span of his life he represented, as no one else in Brazil did, the myth of the Romantic poet and hero.His literary vocation became clear very early on. Coming from a well-to-do family, he studied law in Recife (the capital of Pernambuco), Salvador and (...) São Paulo. He fell in love with a Portuguese actress, Eugênia Câmara, ten years older than himself, and had the deep experience of a love affair with her that shocked the moral provincialism of contemporary Catholic monarchist Brazil. Like many writers of the period he wrote plays, and had great success with the drama Gonzaga, or the Minas Revolution, about the (abortive) attempt to free Brazil from the Portuguese yoke, which had been made in Minas Gerais in the eighteenth century. But it was in poetry – Espumas flutuantes (‘Floating Foam’, 1870) as well as the posthumous A cachoeira de Paulo Alfonso (‘Paulo Alfonso's Waterfall’, 1876) and Os escravos (‘The Slaves’, 1883) – that Castro Alves stood out on the country's literary scene. (shrink)

In this book, Carlos Montemayor and Harry Haladjian consider the relationship between consciousness and attention. The cognitive mechanism of attention has often been compared to consciousness, because attention and consciousness appear to share similar qualities. But, Montemayor and Haladjian point out, attention is defined functionally, whereas consciousness is generally defined in terms of its phenomenal character without a clear functional purpose. They offer new insights and proposals about how best to understand and study the relationship between consciousness and attention (...) by examining their functional aspects. The book's ultimate conclusion is that consciousness and attention are largely dissociated. -/- Undertaking a rigorous analysis of current empirical and theoretical work on attention and consciousness, Montemayor and Haladjian propose a spectrum of dissociation—a framework that identifies the levels of dissociation between consciousness and attention—ranging from identity to full dissociation. They argue that conscious attention, the focusing of attention on the contents of awareness, is constituted by overlapping but distinct processes of consciousness and attention. Conscious attention, they claim, evolved after the basic forms of attention, increasing access to the richest kinds of cognitive contents. -/- Montemayor and Haladjian's goal is to help unify the study of consciousness and attention across the disciplines. A focused examination of conscious attention will, they believe, enable theoretical progress that will further our understanding of the human mind. (shrink)

In this paper, I argue the practice of procreation is immoral regardless of the consequences of human presence such as climate change and overpopulation; the lack of consent, interests and moral desert on the part of nonexistent individuals means someone could potentially suffer in the absence of moral justification. Procreation is only morally justified if there is some method for acquiring informed consent from a non-existent person; but that is impossible; therefore, procreation is immoral.

The aim of our experiment was to analyse the effect of the emotional valence (positive, negative, or neutral) on true and false recognition, matching the arousal, frequency, concreteness, and associative strength of the study and recognition words. Fifty younger adults and 46 healthy older adults performed three study tasks (with words of different valence: positive, negative, neutral) and their corresponding recognition tests. Two weeks later, they performed the three recognition tests again. The results show that words with a negative valence (...) produced less true recognition and less false recognition than words with a positive or neutral valence, in both younger and older adults, on the immediate recognition test. This pattern of results was also found in the younger adults on the delayed recognition test, whereas in the older participants, these differences disappeared. Thus, when arousal is controlled, both younger and older adults tend to recognise negative information worse than positive or neutral information, but they also commit fewer errors. Results would suggest that the greater arousal commonly associated with negative stimuli, rather than their own valence, could explain some of the contradictory results found in the literature. (shrink)

The definitive account of Aristotle's life and school This definitive biography shows that Aristotle's philosophy is best understood on the basis of a firm knowledge of his life and of the school he founded. First published in Italian, and now translated, updated, and expanded for English readers, this concise chronological narrative is the most authoritative account of Aristotle's life and his Lyceum available in any language. Gathering, distilling, and analyzing all the evidence and previous scholarship, Carlo Natali, one of the (...) world's leading Aristotle scholars, provides a masterful synthesis that is accessible to students yet filled with evidence and original interpretations that specialists will find informative and provocative. Cutting through the controversy and confusion that have surrounded Aristotle's biography, Natali tells the story of Aristotle's eventful life and sheds new light on his role in the foundation of the Lyceum. Natali offers the most detailed and persuasive argument yet for the view that the school, an important institution of higher learning and scientific research, was designed to foster a new intellectual way of life among Aristotle's followers, helping them fulfill an aristocratic ideal of the best way to use the leisure they enjoyed. Drawing a wealth of connections between Aristotle's life and thinking, Natali demonstrates how the two are mutually illuminating. For this edition, ancient texts have been freshly translated on the basis of the most recent critical editions; indexes have been added, including a comprehensive index of sources and an index to previous scholarship; and scholarship that has appeared since the book's original publication has been incorporated. (shrink)

The main thesis of this paper is that two prevailing theories about cognitive penetration are too extreme, namely, the view that cognitive penetration is pervasive and the view that there is a sharp and fundamental distinction between cognition and perception, which precludes any type of cognitive penetration. These opposite views have clear merits and empirical support. To eliminate this puzzling situation, we present an alternative theoretical approach that incorporates the merits of these views into a broader and more nuanced explanatory (...) framework. A key argument we present in favor of this framework concerns the evolution of intentionality and perceptual capacities. An implication of this argument is that cases of cognitive penetration must have evolved more recently and that this is compatible with the cognitive impenetrability of early perceptual stages of processing information. A theoretical approach that explains why this should be the case is the consciousness and attention dissociation framework. The paper discusses why concepts, particularly issues concerning concept acquisition, play an important role in the interaction between perception and cognition. (shrink)

Grit, which is originally conceptualized as passion and perseverance for long-term goals, has been associated with optimal performance. Although previous meta-analytic and systematic reviews summarized how grit relates to performance outcomes, they possess considerable shortcomings, such as (a) absence of summary on the association of grit with well-being outcomes; (b) absence of discussion on social, psychological, and emotional mechanisms linking grit to well-being; and (c) lack of elaboration on how alternative models can resolve fundamental problems in the grit construct. This (...) integrative review provides a comprehensive summary on the link of grit to performance and well-being outcomes. Importantly, it elaborates how alternative models can potentially address flaws in the existing grit theory. Future research directions are discussed on how to move forward the science of grit. (shrink)

Mit dem Untertitel »Streitfragen« bringt dieser Band 44 der Fichte-Studien eine Gruppe von Beiträgen, die das Hauptthema »Fichte und seine Zeit« behandeln und es aus unterschiedlichen Gesichtspunkten entfalten.

Dieser Band ist in vier Teile gegliedert, die dem theoretischen, praktischen und politischen Gedanken des Philosophen gewidmet sind. Diesen folgen im vierten Teil Beiträge, die Fichtes philosophische Ansätze in den Dialog mit gegenwärtigen Autoren und Fragen der Philosophie bringen.